Which statement best describes familial hypercholesterolemia (FH)?

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Prepare for the PLTW Biomedical Science Test. Study with flashcards and multiple choice questions, each question comes with hints and explanations. Get ready for your exam!

Multiple Choice

Which statement best describes familial hypercholesterolemia (FH)?

Explanation:
Familial hypercholesterolemia is a genetic disorder caused by mutations in the LDL receptor gene, which reduces the liver’s ability to remove LDL cholesterol from the bloodstream. Because LDL clearance is inefficient, LDL stays elevated, driving early atherosclerosis and increasing the risk of coronary artery disease. Each statement reflects an aspect of FH: it is genetic; it involves a gene for LDL receptor proteins; and the impaired removal of LDL leads to buildup and CAD. Taken together, all of these describe FH, so the best choice is that all of the above statements are true.

Familial hypercholesterolemia is a genetic disorder caused by mutations in the LDL receptor gene, which reduces the liver’s ability to remove LDL cholesterol from the bloodstream. Because LDL clearance is inefficient, LDL stays elevated, driving early atherosclerosis and increasing the risk of coronary artery disease. Each statement reflects an aspect of FH: it is genetic; it involves a gene for LDL receptor proteins; and the impaired removal of LDL leads to buildup and CAD. Taken together, all of these describe FH, so the best choice is that all of the above statements are true.

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