In homozygous dominant FH, LDL levels are typically?

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Prepare for the PLTW Biomedical Science Test. Study with flashcards and multiple choice questions, each question comes with hints and explanations. Get ready for your exam!

Multiple Choice

In homozygous dominant FH, LDL levels are typically?

Explanation:
Homozygous familial hypercholesterolemia causes extremely high LDL because both copies of the LDL receptor gene are defective, so the body can’t clear LDL from the blood effectively. This impairment starts early, so LDL cholesterol levels rise to very high values, typically well above 600 mg/dL. That dramatic height of LDL is a hallmark of the condition, far exceeding normal ranges and those seen with milder or single-gene forms.

Homozygous familial hypercholesterolemia causes extremely high LDL because both copies of the LDL receptor gene are defective, so the body can’t clear LDL from the blood effectively. This impairment starts early, so LDL cholesterol levels rise to very high values, typically well above 600 mg/dL. That dramatic height of LDL is a hallmark of the condition, far exceeding normal ranges and those seen with milder or single-gene forms.

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